For an X-linked recessive disorder to affect a female, the X chromosomes from both parents must carry a certain genetic mutation. If a female receives one mutant and one normal X chromosome, the normal copy is usually able to compensate for the mutant copy. Because males have only one X chromosome, however, only one X-linked genetic mutation needs to be inherited for a male to be affected with an X-linked recessive disorder. Therefore, X-linked recessive disorders are more common in males than in females.
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